Chitosan is widely used polymer for controlled and sustained release drug delivery system. Chitosan is a deacetylated derivative of chitin, which produce chitosan by deacetylation on treatment with alkali. Chitoan is the second most abundant polysaccharides after cellulose. Chitosan is widely used in different fields like industry, cosmetics, medicine etc. Chitosan can be modified by either chemically or enzymaically. Modified derivatives of chitosan have shown good sustained and controlled release drug delivery. Modified chitosan has many advantages over ordinary chitosan such as higher aqueous solubility, mucoadhesive strength, intestinal permeability or higher absorption of neutral & cationic peptides analogue over wide range of pH. Chitosan has also shown many applications in various targeted drug delivery system like colon, gastro intestinal, buccal, dental etc.
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